Yes. I was diagnosed with an "aggressive" breast cancer in Fall 2014 at stage IIIc and began the full journey (tired of that word) of mastectomy, chemo, radiation, and then continuing with the aromatase inhibitor - anastrozole - long-term. There was a brief hospitalization with neutropenia after a toxic reaction and a little scaling back my chemo dosages. I finished treatment in May 2015, and it was a couple years before I got past feeling fragile, and gradually came back to activity. My oncologist wants me to stay on the anastrozole because of the late stage at diagnosis, and I tolerate it well (whew). These days I walk and bike and am part of a long-term study of cancer survivors and the benefits of physical activity. The study paid for my Fitbit!
So, it absolutely DOES NOT always come back. And, maybe a strange insight - I'm not sorry I went through that.