Yes I had a needle guided biopsy - it was mostly painless. They used ultrasound to identify location, took the core sample, then inserted a marker as part of the procedure so it would be visible during all future scans. It was slightly uncomfortable keeping my arm in that position - but the technician and the assistant that was in the room to help me stay calm was most helpful. I was extremely scared - I had not told anyone I was having the procedure so I felt alone. I believe I left with an ice pack and since COVID was still around I was working remotely and returned to work afterwards - my mind was elsewhere so I was only slightly productive - but it wasn't because of discomfort. I believe they suggested I use ice packs or bags of frozen peas for several hours to prevent swelling. Afterwards I only took Tylenol for discomfort. They numb the site and that was when you feel the pin prick of the needle.