In my case, my digestive tract cells were hypertrophic, meaning enlarged and not good. PPI's in general from what I learned can cause a variety of ill health effects - fractures, pneumonia risk, risk of C.difficile and iron and B12 deficiency as well as possible cancers. I had been on the PPI for 6 months and was concerned about continuing to use it as I didn't feel much better. My doctor listened and contacted GI and scheduled an endoscopy. It was my 3rd endoscopy over the course of 7 years dealing with indigestion and one and off acid reflux.