Hi!
My father has been on this regimen since March. He had a marked decrease in in CA 19-9. Recent scan in June showed mixed response. His primary tumor reduced, along with nearby lymph nodes. However, some areas in his liver grew, and two new mets to the liver. He tolerated it well. Was hardest on his platelets; had a dose reduction and has had to skip infusions here and there for platelets to recover first. Thankfully, he experienced no diarrhea. Irinotecan is know to cause that, but I believe the liposomal is better in this regard.