Why are dosages for estrogen suppression drugs one-size-fits-all?

Thanks for posting this info and link! I would really like to find the original article with the clinical data. I came across a 1996 article, very small groups, also about dosing and am wondering about the 'below level of detection' difference betw .5 and 1 mg of Arimidex, but which is mentioned that result found 24 hrs after last dose...so doesn't explicitly mention if that was also the case during the 14-day testing period....(study funded by Zeneca, btw)

Arimidex (ZD1033): a selective, potent inhibitor of aromatase in postmenopausal female volunteers
RA Yates', M Dowsett2, GV Fisher', A Selen3 and PJ Wyld4 'Zeneca Pharmaceuticals, Alderley Park, Macclesfield, Cheshire SKIO 4TG, UK; 2Royal Marsden Hospital, Fulham Road, London, SW3 6JJ, UK; 3Zeneca Pharmaceuticals, 1800 Concord Pike, Wilmington, USA; 4Inveresk Clinical Research Ltd, Riccarton, Edinburgh, UK.
Summary
Two multiple-dose studies were conducted in healthy post-menopausal female volunteers to investigate the pharmacokinetics and effects on endocrinology of Arimidex (ZD1033). Volunteers in the first trial were dosed with 3 mg of ZD1033 daily over 10 days to assess the effects on endocrinology of ZD1033 and establish the pharmacokinetic profile. In the second trial volunteers received 14 daily doses of either 0.5 or 1.0 mg of ZD1033 to assess the pharmacokinetics of ZD1033 and the effects of low doses of ZD1033 on serum oestradiol concentrations. Following multiple dosing a significant reduction in the concentration of serum oestradiol of approximately 80% of baseline was obtained with all three doses; no recovery in oestradiol was apparent for up to 144 h after the last dose. There was no overall difference in the level of oestradiol suppression between the 0.5 or 1.0 mg doses of ZD1033. However, comparison of the number of volunteers with oestradiol concentrations below the limits of detection of the assay, 24 h after the last dose of ZD1033, suggested that 1.0 mg was the minimal dose required for maximal suppression of oestradiol.

Thank you for planning to share the articles. My symptom is left leg pain and now left jaw pain when eating. These seem very odd and may not be related.

Thank you for sharing your experience. I found it very interesting. There are few references to jaw pain as a side effect of anastrozole. After taking anastrozole 6 weeks, I also developed jaw pain when eating. I did not see it listed as a side effect, so I did not think it was related to this drug. I thought that I had TMJ, so I made an appointment to see an ENT specialist. I was experiencing many other side effects from anastrozole, so I had stopped taking it after 2 1/2 months. I saw the ENT 2 1/2 weeks after stopping anastrozole. By then, my jaw pain had subsided substantially. The ENT said that my jaw pain was not caused by TMJ. Joint pain is a well-known side effect and the jaw is a joint. Estrogen protects joints and reduces inflammation. When an aromatase inhibitor lowers estrogen to undetectable levels, it seems to me that any joint could be affected.
BTW - My former oncologist would not acknowledge that my jaw pain or any of my other numerous side effects could be caused by anastrozole. However, they all went away after I stopped taking it. I now have a wonderful new oncologist.

Thank you for sharing your experience. I found it very interesting. There are few references to jaw pain as a side effect of anastrozole. After taking anastrozole 6 weeks, I also developed jaw pain when eating. I did not see it listed as a side effect, so I did not think it was related to this drug. I thought that I had TMJ, so I made an appointment to see an ENT specialist. I was experiencing many other side effects from anastrozole, so I had stopped taking it after 2 1/2 months. I saw the ENT 2 1/2 weeks after stopping anastrozole. By then, my jaw pain had subsided substantially. The ENT said that my jaw pain was not caused by TMJ. Joint pain is a well-known side effect and the jaw is a joint. Estrogen protects joints and reduces inflammation. When an aromatase inhibitor lowers estrogen to undetectable levels, it seems to me that any joint could be affected.
BTW - My former oncologist would not acknowledge that my jaw pain or any of my other numerous side effects could be caused by anastrozole. However, they all went away after I stopped taking it. I now have a wonderful new oncologist.

Indeed ‘one size fits all’ is the first abstract question that probably occurs to all and rightfully so. Once you find this understanding - your deeper needs and understandings are regarding side effects and are the challenge confronting us. Making your search concerning each side effect is the toughest endeavor. Prioritizing them, dealing with what you can. Collaboration can be helpful - or it can be another side effect in your need to make the decision for YOU!

This is the extra layer of understanding and concern that is preaching to the choir - fair enough if that is all you can offer. 🤷🏼‍♀️