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Clinical trial (third line treatment) lurbinectedin and irinotecan

Pancreatic Cancer | Last Active: Jun 27, 2023 | Replies (29)
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@ro0891

Blood did not reach expectations today. Albumin remained low. We have no choice but to give up on this particular trial. Cancer is growing too fast to wait another two weeks. Dr. Decided to put my father back ok chemo but a different regimen. Since gem/Abrax wasn’t working to well he is going to be on liposomal irinotecan 5-fu. Does anyone have experience with this combo of drugs?

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Replies to "Blood did not reach expectations today. Albumin remained low. We have no choice but to give..."
brittbk | @brittbk | Jun 21, 2023

Hi!
My father has been on this regimen since March. He had a marked decrease in in CA 19-9. Recent scan in June showed mixed response. His primary tumor reduced, along with nearby lymph nodes. However, some areas in his liver grew, and two new mets to the liver. He tolerated it well. Was hardest on his platelets; had a dose reduction and has had to skip infusions here and there for platelets to recover first. Thankfully, he experienced no diarrhea. Irinotecan is know to cause that, but I believe the liposomal is better in this regard.

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