Tymlos side effects I've encountered

I am a physician on tymlos for 6 months. Three months ago, I began having back, knee, shin and ankle pain. Prior to that time, I was extremely active and these symptoms have reduced my activities by about 50%. I have seen a podiatrist, orthopedic surgeon, neurologist, internist and rheumatologist. I do have mild L4 foraminal stenosis and knee chondromalacia, but these pains are more frequent, severe and extensive than the orthopedic changes.

I am considering stopping tymlos for 1 month to see if it is the cause of these symptoms. I would be interested in hearing if others have experienced something similar to this.

I am a physician on tymlos for 6 months. Three months ago, I began having back, knee, shin and ankle pain. Prior to that time, I was extremely active and these symptoms have reduced my activities by about 50%. I have seen a podiatrist, orthopedic surgeon, neurologist, internist and rheumatologist. I do have mild L4 foraminal stenosis and knee chondromalacia, but these pains are more frequent, severe and extensive than the orthopedic changes.

I am considering stopping tymlos for 1 month to see if it is the cause of these symptoms. I would be interested in hearing if others have experienced something similar to this.

I have been on Tymlos for seven weeks now. I have started to experience lower back pain and pain in my left hip (I have AVN on that hip). I started on a very low dose (3 clicks) and added a click every three days. At 6 clicks, I started to experience some side effects. I had a few terrible days with nausea, leg cramps, general malaise, and even "hot flashes". At 7, it was a disaster. I had to skip a day and go down to 5 for a few days. I am back at 6 clicks. The first days were not good: nausea, leg cramps, back and hip pain, and, again, the "hot flashes". But I stuck to my treatment, and the effects have gradually subsided. Only mild nausea and feeling a bit tired, especially in the late afternoon. I plan to hang on at 6 a little bit more to see if my body gets used to it completely, and I'll try 7 clicks one more time. Not really looking forward to trying the full 80 mcg. though.

@windyshores Did you experience side effects? How did you manage them?

@gwpitt is it possible these are "growing pains." That was suggested to me. For me the pain was worse in those first 6 months when the growth was greatest.

Rather than stop, I would reduce the dose by one or two clicks, meaning over time I mostly did 6 or 7 clicks of the pen. I was amazed how much worse side effects were at the full 8 clicks so I did that only rarely. I still had 20% gain in my spine. Maybe you could try going down rather than stoppint?

Windshores:
That was a very astute point. When you look at the Tymlos literature provided by the company, bone mineral density increases 5.9% (in women) in the first 6 months. It increases to 8.2% after 1 year and 9.2% after 18 months. Although I am male, the data should be fairly close. Also, males seem to have more reported bone pain than females.
My symptoms seem to be slowly improving and I am attributing this to less bone growth and a flattening out of the curve. Reducing the dosage is also a great suggestion.
Thanks for your input.
Gswpitt.

Windshores:
That was a very astute point. When you look at the Tymlos literature provided by the company, bone mineral density increases 5.9% (in women) in the first 6 months. It increases to 8.2% after 1 year and 9.2% after 18 months. Although I am male, the data should be fairly close. Also, males seem to have more reported bone pain than females.
My symptoms seem to be slowly improving and I am attributing this to less bone growth and a flattening out of the curve. Reducing the dosage is also a great suggestion.
Thanks for your input.
Gswpitt.