Yes. Sometimes, after taking Actemra for a while your body begins to reject it and can cause hives. I had a very bad breakout last summer from something and my Rheumatologist thinks it MIGHT be a reaction to the Actemra. Prescribed OTC Zyrtec (or similar) the day prior, on, and day after my injection. I usually wait until I see if I need it and then take just one. Most of the time, my skin has been sensitive since taking Actemra, but I can usually control it by a topical application of a lotion containing aloe. I know my body reacts somewhat to the Actemra because, once in a while, I get a small itchy bump at the injection site. I've been on it for a year and 8 months. Reaction started about 8 months ago. Prednisone has too many side effects to list. High blood sugar, swelling legs, overall cushiness to name a few.