I was stage 1 and had 12 rounds of Folferinox after distal pancreatectomy, hope was that the chemo would chase down any cancer cells, but it still spread to my liver, so on Gemzar and Abraxane for 2.5 months so far. My experience with Folferinox was that I was feeling lousy for about 5 days, then much better until next round. The Gemzar/Abraxane is less predictable and more cumulative as far as side effects. I think the fatigue is more intense than with Folferinox (still have neuropathy from the Oxaliplatin four months since ending that treatment). Hair fell out from Abraxane, but cumulative fatigue is the biggest side effect from Gem/Abraxane. I am 67 years old and that is my experience, and the doctors were always open to skipping rounds if I felt too weak. I hope this is helpful. Best wishes.