I am so pleased you reached out. My answer based on months of questions, seeing other doctors etc. is no. If this is happening to anyone, no one is talking about it. What I have found is that none of the many doctors and nurse practitioners were aware of the tissue size requirement of the tumor. If they were somewhat aware, they didn't know the different average sizes of tumor biopsy specimens produced by the various modes of biopsy. What needs to be well known by the doctors and surgeons is to make sure their patient has enough unfettered, unexposed to AI tissue to insure that an Oncotype DX test is possible if needed. I now find out I will never know even after 5 yrs if I need to continue the letrozole. I am flying without a seatbelt...I feel as if I have no clear prognosis and have had to accept this. If you would like to discuss my findings further...please feel free. I don't think I am allowed to give you my contact info.