Does small vessel disease cause fatigue and inability to function normally? SVD of brain has made me extremely tired and weak in limbs. Not depressed and pain is bearable. Have had tests commonly done but extensive white matter changes, an old lacunar infarct, is about all I know that is for sure. My biggest problem is with unrelenting fatigue. Some days I can't force myself to do anything. I don't find much info reported about the fatigue. Can anyone tell me if this is part of brain disease?? I am 66 and find it harder to keep going. I have lots of things I would like to do and simply don't have the energy. I understand brain fog and some symptoms. Family members had heart disease and Alzheimer's which I have to guess is related in some way. Fatigue was not this extreme for my loved ones. I don't want to give up trying to press on and don't expect a miracle but I hate to assume there is nothing I can do if I have missed something. Thanks and good wishes to you all.

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