This is from the same writer of the last comment. The details are as follows. After day four of Levaquin, an attempt to heal UTI. I had a Immediate Neuropathy in my feet and my hands. My mental status changed drastically. I could no longer focus at work. I could not remember all the things that were hardwired in my mind, I could not use a computer and I could not treat patients as I had for the last 30 years. I had seen a spectrum of physicians as had many contacts. Other than the obvious neuropathy. My other complaints were ignored. Inability to sweat, lizard type skin I was talked down to and neglected when I told them the massive number of cognitive changes that it happened. I did cognitive testing for my entire career of over 30 years. My executive functioning skills quickly went down with motor apraxia and ideational apraxia all kinds of mental symptoms. The extreme weakness from being a half marathoner, to barely being able to walk slowly due to the tendon, soreness and tightness in my whole body. When the allopathic physicians could not figure out what was going on. They threw me in the mental category. Suggested that I went to a behavioral facility where things went extremely bad. My weakness and pain from previous UTI returned severely, and at one point I actually attempted suicide. They sent me to a lockdown facility at that time which was very nasty and did not assist me in anyway. I was put on very destructive anti-depressant antipsychotic drugs and benzos to assist in sleep, which was totally destroyed since the Levaquin became a total insomniac. Sometimes could not sleep for a week at a time not even for an hour. Again, all the symptoms were so extreme and so severe. I’ve only worsened to this day. Stopped driving vision from being good is now severely impaired. It is affecting my entire body function. I have many central nervous system problems as I no longer have a reflexive cough or reflexive sneeze. multiple auto immune type symptoms. Only the naturopathic doctor seems to have a clue. I have tried multiple supplements with minimal results. The muscle wasting is phenomenal and I have gone from solid rock to pure cellulite and do not engage in normal community life functions anymore. Tried strengthening exercises, and things just got worse. I could pound out several bar dips or pull ups. Now I can do none. This seems to be like a progressive neuro physiological issue. I can’t coordinate shaving or simple ADLs. I just go from the bed to the bathroom to the kitchen and stare at the ceiling. I was the most active stable person and a high functioning individual you will ever find. Highly engaged in world events, news politics, everything. Also, an avid bowler . It all ended after Levaquin. The allopathic doctors just deflect deny or can’t understand it. It has really made me want to scream. As people just do not believe how so many resulting symptoms can happen. But with mitochondria depletion, I would think nothing is off the table as in my case. But nobody can seem to put their finger on exactly what it is. But my total body dryness and lack of saliva, it is very similar to Sjogren’s syndrome symptoms. Was 60 years old going on 40 with zero health or mental issues. After day four of Levaquin it is phenomenal what happened to me. My wife has done everything for me since that time. I am essentially bedbound and ignore the world around me. Have not gone to a store or a bank or interacted other than a few doctors appointments which I was dragged to as I have become extremely socially impaired. The anhidrosis almost entire body unable to sweat affects everything. I do have bad psych issues now. But it all stems from the onset after the Levaquin. If there is anyone out there who has suggestions for one that is 3 1/2 years post onset please let me know.

Welcome @xerky1024, I'm sorry you had to retype your post. I'm not sure what happened but thank you for taking the time to type your story again. I can't even begin to imagine how difficult it has been for you to be given something that was meant to help you get rid of a UTI and then ends up being your worst nightmare.

I know you've done a lot of research but I thought I would share a few links in case you haven't seen them.
--- Treatment of the Fluoroquinolone-Associated Disability: The Pathobiochemical Implications: https://www.semanticscholar.org/paper/Treatment-of-the-Fluoroquinolone-Associated-The-Michalak-Sobolewska-W%C5%82odarczyk/9eea355de62ed4adf184a9dd80bf7b07e1e0637b
--- Antioxidant therapy in the management of fluoroquinolone-associated disability: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7667412/

Mayo Clinic Rochester also has a clinical trial that is active:
--- A Study to Evaluate Biomarkers of Fluoroquinolone-induced Mitochondrial Toxicity: https://www.mayo.edu/research/clinical-trials/cls-20464386.

Have you done any research or tried any treatments to help with your neuropathy or Sjogren's symptoms?