Hi Newbie, When I started with prednisone I did read that it could affect sleep. With that in mind, I took my whole dose 30mg (one week at this amt.) in the AM (7:30-8:00). I was careful to eat something first, usually a banana, and take meds with a glass of milk. So far no change in sleep patterns or gastro issues. I am now at 17.5 and (fingers crossed) doing fine, still taking the whole dose in the morning. I want to mention that I am also taking a boatload of supplements. Before PMR I was med free, only taking a daily Vit D3 and occuvite (eye health). Now, as I think I mentioned, I have added 1000 calcium, more vit D, vit K, occuvite, Pepcid (20mg) and of course prednisone. The Pepcid is a new addition because rheumatologist said long term prednisone use (more than one week) could cause stomach bleeding and the Pepcid is a preventative measure. So now I am feeling like the old person with the pill container full of stuff that I have to manage everyday. However, if this regimen helps to put PMR into remission, I will be a happy camper. Good luck. Liz Ward from VA

Curious, did your doctor recommend splitting the dose? My dad (he has PMR; I am a caregiver) took his initial 20 mg dose in the morning and be really couldn’t sleep because he’s so sensitive to medication. He really wouldn’t have been able to tolerate taking any amount later in the day. At one point, his doctor recommended trying it, thinking he’d “sleep through” before the side effect kicked in and woke him up, but it only made it worse >_< But everyone’s different, right?