Cortisone increase blood glucose levels thus possibly increasing an inflammatory response if you have insulin resistance and an overworked pancreas. Recently got a continuous glucose monitor and started a low carbohydrate meal plan. Pain is reducing in OA knees and I feel my depression lifting. I hope it continues because I found that with the exception of this last doctor I visited, physicians do not connect the dots in their specialty area to inflammation. It’s surgery or a medication in most every instance.