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Breakthrough Pain?

Polymyalgia Rheumatica (PMR) | Last Active: Jun 15, 2023 | Replies (18)

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@nyxygirl

@vellen I think you would get a lot out of looking at this site : https://www.pmrandil6.com/ click through the top tabs over to resources and and scroll down to find the Video About the Pathophysiology of PMR and the Role of Elevated IL-6 in PMR.
I like this figure (below) from Lundberg et al 2022.

Steroids inhibit T-cell activation, proliferation and polarization into Th17 cells. In
addition, they trigger a decrease in the level of serum IL-6.
There are many of us, recently Diagnosed, that did NOT respond 100% to 15 or 20mg prednisone - a rheumatologist increased dose to 30mg for me - the miracle no pain no stiffness occurred next day !! {PS - it appears that a PCP is reluctant to go higher than 15 mg Prednisone - ASK your doctor to go higher ! - see if he/she says you would then need a Rheumatologist consult }
And you need to keep a pain journal ( I can give you some ideas if you wish ) - good luck !!

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Replies to "@vellen I think you would get a lot out of looking at this site : https://www.pmrandil6.com/..."

I'm not keen on seeing a rheumatologist only for the fact that I live out in the country in a small town and it would be an hour and a half drive minimum round trip.