Hi @lanieg, I'm sorry to hear that the prednisone is messing with your blood glucose. That is definitely the pits. It's just my own opinion but I don't think CBD or THC will do anything to treat the cause of PMR to get you to remission but it may mask the pain. Hopefully other members may have some experience to share with you. There are a couple of other discussions that might be helpful when you are struggling to taper off of prednisone or need alternatives.

--- PMR: Are there treatment alternatives to Prednisone?: https://connect.mayoclinic.org/discussion/alternatives-to-prednisone/
--- PMR Dosages and Managing Symptoms: https://connect.mayoclinic.org/discussion/pmr-dosages/

Hi there- That’s rough managing both conditions. I don’t believe there’s much (if any) research to show cannabis or CBD would address the root cause of the PMR, but it could help with pain while you continue to try to taper. I’ve had some success with CBD topical cream (I’m sensitive to medication, so too nervous to try oral CBD or anything more), but everyone is different. It’s always been as an adjunct to medication, not a replacement though.

We’ve had some concerns with my A1C going up, and my dietician has suggested some other strategies such as increasing my intake of green tea, building up my strength training (muscle mass helps lower blood sugar), and gently adjusting when I have starchy foods. I’m not a diabetic though, and at risk of developing disordered eating, so that’s why her recommendations are more of the “gentle nutrition” variety, but thought I’d mention it in case any of this might help.