My husband is using Aveeno and Aquaphor lotions. Seem to be helping with dryness. Don’t forget sunscreen on tops of hands too. He’s having his 5th round of Folfirinox on 6/13. Wishing you wellness on this hard journey.

@wjk : The info binder my onc gave me doesn't recommend a specific lotion or cream, but fwiw over the years I've had the best results with Neutrogena's Norwegian hand cream (better than the lotion, which is also good). The cream feels unpleasantly greasy for a few minutes (from the lanolin, I think) but that wears off as it is absorbed, and the cream works as nothing else has.

I haven't tried it during chemo bc so far, knock wood, no skin problems. Perhaps just make sure that your onc has no objections to it? (I think it's very safe -- I use in on my chapped lips, too -- but I don't want to inadvertently cause anyone any problems.) Best wishes to you.