I have been on Anastrazole/Arimidex for one year. I've had some joint pains but nothing unmanageable. I do notice my hair thinning likely due to less estrogen. I have recently been diagnosed with Gilbert's syndrome due to a slightly elevated bilirubin, which is a condition in which the liver doesn't flush bilirubin out sufficiently resulting in yellowing of the whites of your eyes or yellowing skin. I have a question out to my doctor about next steps but would be interested in hearing if any others have had this particular issue arise while on Anastrazole. Best wishes to all of you!