Hi @usveteran, Welcome to Connect. I'm not sure if the article you were looking for is one of these but they are on the same topic and may be helpful.

--- How can proton pump inhibitors damage central and peripheral nervous systems?: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7716020/
--- Drug-Induced Peripheral Neuropathy: A Narrative Review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365998/.

There is another discussion on the topic where you can learn what others have shared on the topic here:
--- Neuropathy + Proton-pump Inhibitor use?? Anyone had this experience?: https://connect.mayoclinic.org/discussion/neuropathy-and-ppi-use-has-anyone-had-this-experience/.

Is it only the one toe with the pain symptoms? Do you think it something other than neuropathy?

Well I started out with both pinky toes having neuropathy for years. Was manageable. Slept in the guest room one night and woke up to total neuropathy in both feet!! Still have it. Freaking nightmare. However after the MRI I just had I think it is probably caused by extreme spinal disk issues!!!!!

I was on the med for 1 and 1/2 years. Checked it out on the internet and, I found out you are NOT supposed to be on OMEPRAZOLE for more then 4 weeks at a time!
I contacted my PCP and told him I wanted off the med! He ordered it prn.
After hearing your tale, I will NEVER take it again.
I have PN from the tips of my toes, to the top of my calves now. Only in 6 short months.
Thanks for the information. Pat!

Hello, The amount of pain meds you are taking is scary to me. I have neoropathy in 90% of my body and I do not take nearly that amount of meds. If your VA Dr. doesn"t know how to treat it please do not hesitate to see another one. thank you for your service to our country,may God bless you and yours.

I've been on 20 mg of Omeprazole daily for over 10 years. I'm also taking 200 mg Gabapentin. Likewise, I've been concerned about the long term impacts of Omeprazole, but, every time I talk to my GI doc about it, he says the risk of esophageal cancer out weighs any side effects I might get from taking it. Not only that, but I have an autoimmune disease that causes red spots all over my body. The VA diagnosed me with peripheral neuropathy, and Restless Leg Syndrome. I've had exposure to Agent Orange, and assumed much of it came from this exposure. So your post on Omeprazole's side effects is very timely and of interest to me. So I did a ChatGpt search for this subject and came up with the following results.

Here is what ChatGpt came up with: Looking for studies on PPI's that end in 'AZOLES" which are said to have known side affect to cause peripheral neoropathy
ChatGPT said:

Proton pump inhibitors (PPIs), including medications ending in "-azole" such as omeprazole, lansoprazole, pantoprazole, rabeprazole, and esomeprazole, have been associated with neurological adverse events, including peripheral neuropathy.
Evidence Linking PPIs to Peripheral Neuropathy

A large-scale analysis of over 10 million FDA adverse event reports revealed that patients using PPIs had a significantly higher incidence of neurological adverse events compared to those using H2 receptor antagonists. Specifically, the odds ratio for peripheral neuropathy and related conditions was 8.68 (95% CI: 3.86–19.49; p < 0.0001) in the PPI group. This suggests a strong association between PPI use and various forms of neuropathy, including peripheral sensory neuropathy, neuralgia, and polyneuropathy.
PubMed+1PMC+1
PMC+1PMC+1
Case Reports Supporting the Association

Lansoprazole: A case report described a 42-year-old woman who developed burning sensations and dysesthesias in her lower limbs three months after starting lansoprazole. Nerve conduction studies confirmed axonal sensory polyneuropathy. Symptoms improved upon discontinuation of the drug.
SAGE Journals

Pantoprazole: A 70-year-old woman developed peripheral neuropathy and chronic tubulointerstitial nephritis after one year of pantoprazole use. Extensive evaluation ruled out other causes, implicating pantoprazole as the likely contributor.
PubMed+3PubMed+3PMC+3

Rabeprazole: A 28-year-old man experienced bilateral hand numbness, tremors, and muscle stiffness after starting rabeprazole. Symptoms resolved two weeks after discontinuing the medication.
SAGE Journals

Potential Mechanisms

Vitamin B12 Deficiency: PPIs can reduce stomach acidity, impairing the absorption of vitamin B12. Deficiency in B12 is known to cause peripheral neuropathy due to its role in nerve health.

Hypomagnesemia: Long-term PPI use can lead to low magnesium levels, which may contribute to neurological symptoms, including neuropathy.

Direct Neurotoxicity: Some studies suggest that PPIs may directly affect nerve cells or interfere with cellular processes essential for nerve function, though more research is needed in this area.
PMC

Contrasting Evidence

Interestingly, a study investigating the effects of omeprazole in patients undergoing chemotherapy with oxaliplatin found that omeprazole reduced the incidence of peripheral neuropathy in this specific context. In a rodent model, omeprazole ameliorated signs of neuropathy without affecting the anti-tumor efficacy of oxaliplatin. Additionally, analysis of the FDA Adverse Event Reporting System indicated a lower reporting rate of peripheral neuropathy in patients taking omeprazole alongside oxaliplatin.
MDPI+2PMC+2PubMed+2
PubMed+1PMC+1
Conclusion

While there is substantial evidence linking PPI use to peripheral neuropathy, particularly with long-term use, the relationship may be influenced by individual patient factors and specific clinical contexts. Patients on long-term PPI therapy should be monitored for neurological symptoms, and clinicians should consider the risk-benefit profile of continued PPI use in each case.