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@usveteran

I was prescribed OMEPRAZOLE for about 1-2 years from a previous RANIDATIDE prescriprion that was said to be more potent. I developed sensitive peripheral neoropathy at the tip of one toe (second digit/next to great toe). The VA primary doctor has prescribed GABAPENTIN 600mg/day, which I take only prior to sleep. The irritation normally occurs while trying to fall asleep, but sometimes it can irritate while walking or other activity. I quit the OMEPRAZOLE when I found a doctorate's report that said "all the 'AZOLES" have been known in side affect to cause peripheral neoropathy. I found the professional report during a Google search, and I would like some assistance to find that article report again - and if there are any other citations about "the AZOLES" family of PPI's that can complicate a neoropathy condition. Many times now I am seriously considering an amputation rather than saturating my body with up to 1500mg GABAPENTIN + TYLENOL, ASPERIN, and NAPROXEN to boost - and 1 or 2 CYCLOBENZAPRENE that a friend provides in good faith. I get very dizzy from that necessary saturation, and still have to continually massage that toe for a temporary relief. Sometimes I'll end up not sleeping for 24 or 36 hours if I had eaten prior to taking the GABAPENTIN, or did not take enough dosage for an unsuspected severe attack. The GABAPENTIN works best on an empty stomach, and takes a good 2-4 hours to take effect. I have red pimple-like spotted elements all over my skin surface that may be a form of melitus diabeties that may also have pre-disposed me to the neoropathy via introductory affects of the OMEPRAZOLE. I will try to get a VA appointment to see a neoroligist some day, as my VA clinical primary does not have the necessary specialty of this neorologic condition.

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Replies to "I was prescribed OMEPRAZOLE for about 1-2 years from a previous RANIDATIDE prescriprion that was said..."

Hi @usveteran, Welcome to Connect. I'm not sure if the article you were looking for is one of these but they are on the same topic and may be helpful.

--- How can proton pump inhibitors damage central and peripheral nervous systems?: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7716020/
--- Drug-Induced Peripheral Neuropathy: A Narrative Review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365998/.

There is another discussion on the topic where you can learn what others have shared on the topic here:
--- Neuropathy + Proton-pump Inhibitor use?? Anyone had this experience?: https://connect.mayoclinic.org/discussion/neuropathy-and-ppi-use-has-anyone-had-this-experience/.

Is it only the one toe with the pain symptoms? Do you think it something other than neuropathy?

Well I started out with both pinky toes having neuropathy for years. Was manageable. Slept in the guest room one night and woke up to total neuropathy in both feet!! Still have it. Freaking nightmare. However after the MRI I just had I think it is probably caused by extreme spinal disk issues!!!!!

I was on the med for 1 and 1/2 years. Checked it out on the internet and, I found out you are NOT supposed to be on OMEPRAZOLE for more then 4 weeks at a time!
I contacted my PCP and told him I wanted off the med! He ordered it prn.
After hearing your tale, I will NEVER take it again.
I have PN from the tips of my toes, to the top of my calves now. Only in 6 short months.
Thanks for the information. Pat!

Hello, The amount of pain meds you are taking is scary to me. I have neoropathy in 90% of my body and I do not take nearly that amount of meds. If your VA Dr. doesn"t know how to treat it please do not hesitate to see another one. thank you for your service to our country,may God bless you and yours.