@katrina123, I'm sorry to hear you're having such discomfort from Anastrozole. I did too...not nausea or headaches, but pain in shoulder, legs, ankles, feet, hands. Fatigue and insomnia were also a problem. I stayed on it for a year and a half, and then my oncologist switched me to Exemestane and I couldn't tolerate that either. I've now been on Tamoxifen for nearly a year, and the difference is remarkable. I'm 76 next month, so at this point it's hard to tell if the very minor aches and pains, word retrieval problems, and fatigue are from the drug, effects of the quarantine, or just my age! But Tamoxifen is sooooo much better. I know i can tolerate this one until my last year the of drug in 2003.

I also had really bad achy hands on Anastrozole. I switched after 11 months to Exemestane. So far I can tolerate this better - it's been almost a year. I guess the lesson is you never know how it will effect you until you try it. It took more like 3 months for the side effects of anastrozole to go away.