Hi ladies, I believe it is different for everyone. Initially, I had severe joint pain and tried, tamoxifen, and letrozole and then ended up staying on anastrozole. After a few months, I no longer had side effects. There are concerns about AI's decreasing bone density and raising cholesterol. I went off the medication in December after taking it for 5 years. I had hormone-receptive invasive ductal carcinoma with no lymph node involvement. I had a lumpectomy and radiation. My cholesterol still reads the same as it always has and I get a twice-annual injection of Prolia for bone loss. I had a bone density scan and some areas have improved and others have stayed the same. But no worse! I don't have any side effects from the Prolia. I don't feel much different after going off the anastrozole. I took magnesium, calcium, Vitamin D-3, celery root, cherry juice, zinc, and St. Johns Wort throughout the 5 years and continue to take them. I also practice yoga, and meditation daily, light weights, walking, and cycling. Movement is super important for joint pain. It really helps! Especially when you don't feel like it. The aromatase inhibitors really help. They give you protection and "put to sleep" any remaining cancer cells that are hiding. There was a 1.5 per cent difference if I kept taking the medication for 2 more years. I opted not to. 5 years was enough for me. Some treatment is extended to 7-10 years if you had lymph node involvement. I feel good about taking it and they say if you don't have a recurrence after 5 years you are probably okay. Although there's always a chance. Many women have lived for many more years after breast cancer and treatment. I hope we are in that group. Love and blessings to you all. It's a roll of the dice... The oncologists know best. My advice is to take their advice.