I have no interest in sexual intimacy and I am a female. I suffer from chronic depression and anxiety. I have been on Welbutrin XL for several years, over ten. I really noticed not having any interest in sex but decided to ignore it. Months ago, I decided to ween off Welbutrin XL and instead used a holistic substitute. After over a month, the depression and anxiety returned. I have weeks ago resumed taking Welbutrin XL and will take a low dosage of Lexapro. Turns out that not only my antidepressants but also, my high blood pressure medicines and statins are also the culprits for my disinterest. I am unable to not take many of my meds so guess I am going to have to deal with the effects of not having any interest in intimacy.