Anastazole for breast cancer and memory loss?

Posted by rosy54 @rosy54, Mar 3, 2023

Recently, my doctor stopped my Anastrozole after 5 yrs on it for breast cancer.
Since then, my memory is poor and having hard time remembering. I fear I’m developing dementia (68 yrs old) My lack of memory seems worse after stopping Anastrozole. Anyone else have similar problem?

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@ginip

I TOTALLY understand what you are experiencing. I have gone back and forth like a drunken ant and finally made what I call my Sophie’s Choice decision. Anastrozole did not offer me a quality of life that I could move forward with and experience. Prescribers challenged my thinking - I had a hiatus for 2 weeks and I am currently on a 3 month hiatus. Some side effects have ebbed considerably and others such as joint and specifically knees seems more challenging. If I had researched this drug in more detail I believe I would never have taken it. But no one other than the person taking it and experiencing these side effects can possibly realize where we are at this moment - not even myself to begin with. I have now researched how long I should have to deal with side effects once I have stopped taking Anastrozole. It seems that joint and muscle issues can take months. I just worry that while Anastrozole might block estrogen/hormones re Breast Cancer, it’s deprivation of hormones/estrogen in other areas that are deprived of estrogen/hormones aka arthritis in knees, back etc might invite issues. .
I have always been diligent my entire adult life in getting mammos. I of course will continue that diligence. I have an appointment today with a physical therapy group. I have a follow up manmo in September. I will continue to follow all new and exciting efforts to help me keep moving on in the OVERALL both mental and physical way possible. We are women who deserve to carry on through our earned definition of what quality of life means to us. Ever onward!!

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❤️

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Thanks for replying. I had a lumpectomy so I don’t need a reconstruction. The best of luck with ur op x

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@rosa1935

Thank u for replying. I have decided today, 7/6/23, to stop taking Anastrozole fir a month to see how my body reacts. I’ve been on it for 18 months and side effects are getting worse not better. I have done a lot of research and exemestane could b the answer. I’m 71 and I’ve no real quality of life with Anastrozole so it will b interesting to see how I will feel. X

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Good for you! I am 79. I am going to wait the 3 months to see if my hiatus is meaningful in any way. Not going to be motivated to continue at this point.
I am hoping my physical therapy can give me answers in some way.
Stay motivated to search for useful answers.
Gini

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@rosa1935

Thank u for replying. I have decided today, 7/6/23, to stop taking Anastrozole fir a month to see how my body reacts. I’ve been on it for 18 months and side effects are getting worse not better. I have done a lot of research and exemestane could b the answer. I’m 71 and I’ve no real quality of life with Anastrozole so it will b interesting to see how I will feel. X

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Good for you! I am 79 add have been on Anastrozole for 18 months too. I am going to wait the 3 months to see if my hiatus is meaningful in any way. Not going to be motivated to continue at this point.
I am hoping my physical therapy can give me answers in some way.
Stay motivated to search for useful answers.
All the vest
Gini

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Hi ladies, I believe it is different for everyone. Initially, I had severe joint pain and tried, tamoxifen, and letrozole and then ended up staying on anastrozole. After a few months, I no longer had side effects. There are concerns about AI's decreasing bone density and raising cholesterol. I went off the medication in December after taking it for 5 years. I had hormone-receptive invasive ductal carcinoma with no lymph node involvement. I had a lumpectomy and radiation. My cholesterol still reads the same as it always has and I get a twice-annual injection of Prolia for bone loss. I had a bone density scan and some areas have improved and others have stayed the same. But no worse! I don't have any side effects from the Prolia. I don't feel much different after going off the anastrozole. I took magnesium, calcium, Vitamin D-3, celery root, cherry juice, zinc, and St. Johns Wort throughout the 5 years and continue to take them. I also practice yoga, and meditation daily, light weights, walking, and cycling. Movement is super important for joint pain. It really helps! Especially when you don't feel like it. The aromatase inhibitors really help. They give you protection and "put to sleep" any remaining cancer cells that are hiding. There was a 1.5 per cent difference if I kept taking the medication for 2 more years. I opted not to. 5 years was enough for me. Some treatment is extended to 7-10 years if you had lymph node involvement. I feel good about taking it and they say if you don't have a recurrence after 5 years you are probably okay. Although there's always a chance. Many women have lived for many more years after breast cancer and treatment. I hope we are in that group. Love and blessings to you all. It's a roll of the dice... The oncologists know best. My advice is to take their advice.

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@ginip

I TOTALLY understand what you are experiencing. I have gone back and forth like a drunken ant and finally made what I call my Sophie’s Choice decision. Anastrozole did not offer me a quality of life that I could move forward with and experience. Prescribers challenged my thinking - I had a hiatus for 2 weeks and I am currently on a 3 month hiatus. Some side effects have ebbed considerably and others such as joint and specifically knees seems more challenging. If I had researched this drug in more detail I believe I would never have taken it. But no one other than the person taking it and experiencing these side effects can possibly realize where we are at this moment - not even myself to begin with. I have now researched how long I should have to deal with side effects once I have stopped taking Anastrozole. It seems that joint and muscle issues can take months. I just worry that while Anastrozole might block estrogen/hormones re Breast Cancer, it’s deprivation of hormones/estrogen in other areas that are deprived of estrogen/hormones aka arthritis in knees, back etc might invite issues. .
I have always been diligent my entire adult life in getting mammos. I of course will continue that diligence. I have an appointment today with a physical therapy group. I have a follow up manmo in September. I will continue to follow all new and exciting efforts to help me keep moving on in the OVERALL both mental and physical way possible. We are women who deserve to carry on through our earned definition of what quality of life means to us. Ever onward!!

Jump to this post

I went on Anastrozole in October of 2020. By November of 2021 my knee pain was crippling. Literally. In December I made two changes at the same time so I can't be sure which worked. I switched to Letrozole, and I started taking collagen supplements. The improvement happened quickly. I'm 68 so I do have mild arthritis, but to date I mostly experience occasional stiffness if immobile too long. Otherwise I feel my knees are back to where they were pre-Cancer treatment. As you are on a hiatus, adding collagen would provide a clear answer.

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It seems that way to me also, but in doing research, I understand long term Covid effects can include brain fog also. I just keep doing all I can to combat Alzheimer’s (in my family history) and pray, since God is the source of all wisdom! 😊 Oh, and I also have a follow up appt with my memory doctor soon with whom I will ask questions!

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@rosa1935

Did u have any other symptoms on Anastrozole? Like back pain?

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I never had any back pain ( actually no pain at all) just very tired being anemic. It wasn’t till after 5 yrs (on Anastrozole) I noticed how bad my memory had gotten. Im concerned now if I’m headed for dementia at 68

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I believe the memory slowdown happens with age. Try writing everything down I am 75. Just when I think I can remember I can’t then I see friends who weren’t on any cancer meds are worse than I am. Assist your memory loss

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@reneejean

Hi ladies, I believe it is different for everyone. Initially, I had severe joint pain and tried, tamoxifen, and letrozole and then ended up staying on anastrozole. After a few months, I no longer had side effects. There are concerns about AI's decreasing bone density and raising cholesterol. I went off the medication in December after taking it for 5 years. I had hormone-receptive invasive ductal carcinoma with no lymph node involvement. I had a lumpectomy and radiation. My cholesterol still reads the same as it always has and I get a twice-annual injection of Prolia for bone loss. I had a bone density scan and some areas have improved and others have stayed the same. But no worse! I don't have any side effects from the Prolia. I don't feel much different after going off the anastrozole. I took magnesium, calcium, Vitamin D-3, celery root, cherry juice, zinc, and St. Johns Wort throughout the 5 years and continue to take them. I also practice yoga, and meditation daily, light weights, walking, and cycling. Movement is super important for joint pain. It really helps! Especially when you don't feel like it. The aromatase inhibitors really help. They give you protection and "put to sleep" any remaining cancer cells that are hiding. There was a 1.5 per cent difference if I kept taking the medication for 2 more years. I opted not to. 5 years was enough for me. Some treatment is extended to 7-10 years if you had lymph node involvement. I feel good about taking it and they say if you don't have a recurrence after 5 years you are probably okay. Although there's always a chance. Many women have lived for many more years after breast cancer and treatment. I hope we are in that group. Love and blessings to you all. It's a roll of the dice... The oncologists know best. My advice is to take their advice.

Jump to this post

My situation is much like yours ( type and treatment) and I have been taking Anastrozole for nearly a month with no issues. At 64, I have been used to dressing in layers and have always been physically active and am happy to be back to normal exercise routines after finishing radiation May 8.

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