@francine6829 Hi Francine - I'm hoping I do ok on the exemestane..I get 3 weeks off from the Femara and how nice it is. My left knee is hurting less and my hands hurt less. Ankles still a problem but not as bad. If exemestane doesn't work, it's on to Tamoxifen, but doctor is hesitant as my mother had clots in lungs twice in her lifetime so would need to be followed closely. Sounds like many people on Tamoxifen do well.