@baker1 It's odd, I stopped anastrozole because of all the side effects and then began letrozole. Had the aches and stiffness, but just had Zometa infusion on Monday and ankles and hands aren't as bad - could be coincidental as the Zometa caused lots of bone pain and now is subsiding. But I'll sure agree with you, the fatigue is annoying. I try to get out for long walks (3 miles) every other day and swim on the odd days as well as gardening, but find that I have to sit down for bits inbetween what I do. I miss hill hiking, but am not up for that yet.