Trixie, try to get at least 6 weeks without meds. if at all possible. It took me nearly a full month to feel like myself again. If not... oh well...enjoy whatever reprieve you can get!! I did start to feel ‘better’ within about a week, just not quite normal until about 3 weeks being off meds. Thanks for the tip on Femara! Next time I see my oncologist I’ll ask her about it.