Well @tinalove, hopefully you are hanging in with your treatment. I have been on Anastrozole for a little over 2 years. The first 2-3 months were brutal, but then things seemed to get a bit better, so I would encourage anyone who's newly on this drug to stick it out for at least a few months. Over time I have experienced many side effects including joint pain, hot flashes and night sweats, depression and anxiety, vaginal dryness, frequent cystitis, and in the past few months my hair has started thinning significantly. I understand the joint pain can be excruciating for some women; for me it has been manageable. The cystitis is another story; really disruptive for me and I never see anyone else writing about it. The hair thinning has also been pretty distressing. I was ready to call that the last straw and quit the meds, but I just started using Rogaine and am going to give that a few months and see if it helps. My oncologist has been fantastic and done everything possible to help, but not a day goes by that I don't think about quitting this medicine. I just know it is giving me the best odds, so for now I'm going to keep taking it. Re: hair thinning - if anyone out there has finished their AIs and experienced a reversal/improvement in hair thinning, I would love to hear from you. Peace out everyone.