@southtexas @pointer134 @sandiw77 @kberlyhouse and others on Kevzara! Hope you are well !! I found a route to more informative pathophysiology for PMR by looking at titles for GCA! Assuming that because of the more serious nature (vision loss) of GCA, there is/has been A LOT of research there ! And the approval of tocilizumab.

So picture that drug blocking the IL-6, which is (part) of the cause of the inflammation !
And for the rest of us just on Prednisone only -
"Steroids inhibit T-cell activation, proliferation and polarization into Th17 cells. In
addition, they trigger a decrease in the level of serum IL-6."

This article has easy to read Abstract and a nifty figure (Fig 3) showing molecular pathways .
New Insights into the Pathogenesis of Giant Cell Arteritis:
Mechanisms Involved in Maintaining Vascular Inflammation
Hélène Greigert et al. J. Clin. Med. 2022, 11,
2905.