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Concerned about the side effects of anastrozole

Breast Cancer | Last Active: 5 days ago | Replies (1931)

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@sparklegram

@gwinter- Good morning everyone. I wrote several weeks ago to say that I've been on Arimidex for 15 months now and the side effects for me, anyway, are hard to tolerate. Bone and joint pain, weakness in my knees, a general feeling that I've aged about 100 years. (I'm 74 now!) I just wrote a pretty lengthy email to my Oncologist enumerating all these symptoms and more, and asking for her experience and feedback about other choices of AI's. she said other people have fewer side effects from Letrozole and/or Tomoxifen (not an AI)). I know that Arimidex is said to be the most effective in preventing a recurrence, so I am conflicted! I'd love to hear feedback from anyone who has switched from Arimidex to another AI to see if you found relief from side effects.

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Replies to "@gwinter- Good morning everyone. I wrote several weeks ago to say that I've been on Arimidex..."

I lasted a month on Arimidex, I was miserable. Joint pain, insomnia, loss of appetite, nausea, loss of focus; not worth it. I’ve been on Tamoxifen over a month now and am tolerating it well. I understand Arimidex and the AI’s are somewhat better in terms of preventing recurrence, but there is a the quality of life issue. At 65 I want to be active, so I’ll stick with Tamoxifen, it’s better than taking nothing.