Hello, All I can talk to is what happened with me and the cavity I developed. I stayed on the Big 3 and toyed with the idea of Amikacin but after reading about the side effects that could cause hearing loss I decided against it. I stopped nebulizing in November of 2020 and went to Mayo the following February to meet with a surgeon regarding a VAT procedure to remove the cavity. My CT scan showed improvement and the cavity was gone. So, no surgery was required. I had continued to get positive and negative sputum results but my scans looked good and with no change to the MAC clusters. One of the members on here said she had never had a negative sputum test so I stopped that and continue to have CT scans every 6 months. I also stopped taking the medication after 3 years of no change. The azithromycin was also causing hearing loss. I go again this month for another CT to see how things are looking and will not do sputum. I feel pretty good and know that I will stay off drugs until they come up with a better solution. They just didn’t work for me. In the end, I am embracing quality over quantity. Good luck. Carolyn