@gwinter- This is interesting to me, too. I just did a two week trial of going off Arimidex for 2 weeks. I started back on it today. I have been taking it for 14 months with all the side effects we've been reading about on this post. I wanted to see if it was responsible for unbearable leg and knee pain I was having, or if that was being caused by my spinal stenosis. The leg pain did go away after about a week off of Arimidex. I'm waiting to see if it comes back now that I'm back on it To be continued...