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PMR Dosages and Managing Symptoms

Polymyalgia Rheumatica (PMR) | Last Active: Jul 27 8:00am | Replies (468)

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@nyxygirl

Hello all - just got off a zoom call W/Rheumatologist to begin the first "taper" for me 30mg to 27.5 mg. I was interested to see this thread started in 2021 moved to the top with other newly Dx patients such as myself ( onset in mid April, 1st Rheum appointment May 22 ) making commnets. I am not on facebook , I am on medical leave of Absence now, so aside from logging into e-bird , the benefit of reading and writing about PMR with this group is so HELPFUL ! @walkamok I am a Molecular Biologist and I have to say, I never thought to plot my pain data !! : ) I could show your graph in Lab Meeting!

What I want to share here, and on then again, on PMR and Clinical trials thread is this : A trial in Denmark, where as noted the prevalence, is higher (than in USA) !
Dose Reduction and Discontinuation of Prednisolone Using Structured Treat-to-target Taper in Patients With Polymyalgia Rheumatica
Polymyalgia rheumatica (PMR) has an incidence of approximately 1000/10^6 for persons more than 50 years. Treatment with prednisolone carries several significant adverse effects, and it is therefore essential to taper prednisolone as fast as possible. Systematic treatment strategies (treat-to-target) is the most important improvement of disease management for other rheumatic diseases such as rheumatoid arthritis in the last decades. 2023 could be a better year for PMR awareness overall !

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Replies to "Hello all - just got off a zoom call W/Rheumatologist to begin the first "taper" for..."

@johnbishop the trial link I found is this
ICH GCP
US Clinical Trials Registry
Clinical Trial NCT05636501
Treat-to-target Prednisolon Taper in Patients With Polymyalgia Rheumatica: https://clinicaltrials.gov/ct2/show/NCT05636501

The treat to Target concept is described here for PMR: Recommendation
Treat-to-target recommendations in giant cell arteritis and polymyalgia rheumatica published 2023 - first author Dejaco, C.
https://ard.bmj.com/content/early/2023/02/23/ard-2022-223429