@francine6829 Thank you Francine. My oncologist told me that the effects are not as dire as made out to be. I appreciate you letting me know that not smoking and past history should be weighed in. I have never smoked and no history of blood clots. As I said I have a friend who tolerated it very well she was on Tamoxifen for 5 years and is 6 years out cancer free. This is a very bumpy road and we are all trying to get to the same place hopefully things will smooth out for all of us.