@francine6829 - Hi Francine, My doctor explained that Tamoxifen is the drug that has been around the longest that is usually a drug that I would want. My concerns for myself about Tamoxifen are the warnings about blood clots and uterine cancer. I have a friend that did quite well on it with no effects. As for me when we get to that decision I just may opt out. As you had reactions on Letrozole I'm also leery of any of the drugs and will give them all a try and see how it goes. Good luck with Aromasin hopefully you will do better with it.