I think the timeline is very individual. I moved up from two clicks to 6 in maybe 6 weeks. Can't remember. Then pushed to 7 and stayed at 7 clicks. Some days I did 6 if I had something important to do. You are not going to be totally without side effects but it can be tolerable for many of us with this ramping up. I still cannot do full dose but had excellent results after 18 months.