@joanalc , I'm not a doctor, so I couldn't tell you if that's appropriate or excessive, but it does sound aggressive, which might be good, as long as he's in good enough shape to tolerate it.

How long has it been since your husband's Whipple and last CT scan? Are you also testing CA19-9 and ctDNA (Signatera or similar) regularly?

What chemo meds was he on for 6 months after Whipple? What pills are they putting him on now, and why? Did he have any genetic mutations (KRAS, BRCA, ATM, etc) they're trying to target with the new pills?

What are they targeting with the radiation, and why?

The radiation is something I would definitely question, because they have to have something to aim it at. It sounds to me like the oncologist saw something on the CT scan that was concerning but not yet definitive, and wants to exercise every precaution possible.

FWIW, I also had a successful Whipple at Stage-2 after 6 months of Folfirinox, with clean scans, ctDNA tests, and good CA19-9 for 3 months afterward. (No adjuvant chemo or radiation after the Whipple)

But at the 4th month, MRI spotted a new 2 cm tumor where my Whipple was done, even though the other tests and another biopsy were still all normal. PC is a sneaky bastard, to say the least. By the time we did another MRI 6 weeks later, all the blood tests and MRI said the cancer was definitely back, and had spread as well. Stage-4 for me now. 🙁

Based on that experience, I wish I had done some kind of treatment after the Whipple, despite being NED. There's a term "MRD" (Minimal Residual Disease or Microscopic Residual Disease, depending on which papers and websites you read) that describes remaining cancer that is undetectable but can definitely come back and multiply. As @stageivsurvivor will attest, sometimes you have to beat the disease into submission and beyond.

I wish you and your husband well with the treatment, but it sounds like your oncologist could do a little better with the communication. Answers to the questions above would help shed some light.