← Return to Polymyalgia Rheumatica (PMR) - Clinical Trials

Discussion

Polymyalgia Rheumatica (PMR) - Clinical Trials

Polymyalgia Rheumatica (PMR) | Last Active: Mar 19 7:18am | Replies (12)
Comment receiving replies
@nyxygirl

@johnbishop maybe title of this thread should be changed to "trials" in general - 2023 Are people interested to see these ? thank you

IF you are being treated at Yale - you be aware of Monique Hinchcliff, MD, MS-- there is an observation trial collecting blood from patients w/ PMR.

Another approach is anti IL-17 -- this trial has a US site in Spokane -
Secukinumab is a novel biologic agent specifically targeting interleukin-17 (IL-17) involved in a pathological process. It is a fully human monoclonal antibody.

ICH GCP
US Clinical Trials Registry
Clinical Trial NCT05767034
Phase III Study of Efficacy and Safety of Secukinumab Versus Placebo, in Combination With Glucocorticoid Taper Regimen, in Patients With Polymyalgia Rheumatica (PMR) (REPLENISH)
April 12, 2023 updated by: Novartis Pharmaceuticals
A Randomized, Parallel-group, Double-blind, Placebo-controlled, Multicenter Phase III Trial to Evaluate Efficacy and Safety of Secukinumab Administered Subcutaneously Versus Placebo, in Combination With a Glucocorticoid Taper Regimen, in Patients With Polymyalgia Rheumatica (PMR)
The purpose of this study is to demonstrate the efficacy and safety of secukinumab 300 milligram (mg) and 150 mg administered subcutaneously (s.c.) for 52 weeks in combination with prednisone tapered over 24 weeks in adult participants with PMR who have recently relapsed.

Jump to this post

Replies to "@johnbishop maybe title of this thread should be changed to "trials" in general - 2023 Are..."
John, Volunteer Mentor | @johnbishop | May 29, 2023

@nyxygirl - We changed the discussion title to hopefully bring more members together who are interested in what clinical trials are available for PMR. Here is a list of some that I found available on CenterWatch.com:

--- Polymyalgia Rheumatica (PMR) Clinical Trials: https://www.centerwatch.com/clinical-trials/listings/condition/733/polymyalgia-rheumatica-pmr/

VIEW AND REPLY
DadCue | @dadcue | May 29, 2023

It is sad there aren't more treatment options for PMR/GCA. I was told many times that prednisone was the "only option" or the "best option." I took prednisone for more than 12 years for PMR. I asked many times if there was "any other options." The side effects of prednisone were taking a toll on me so I was willing to try anything else.

My rheumatologist had to get authorization to try Actemra (tocilizumab). An exception was made for me because Actemra isn't FDA approved for PMR but it is for GCA. My rheumatologist thought Actemra should work for PMR but didn't know if it would or not.

Actemra worked for me and I was able to taper off prednisone in a year. My rheumatologist thinks I'm better off on Actemra and I would agree.

VIEW AND REPLY