@southtexas @sandiw77 @pointer134 @johnbishop Good afternoon all - the weather is beautiful today in Boston area! I'm pinging a few of you who have said they are starting Kevzara. I started a post called " Can we make PMR funny ? Can we fight the immune cells involved ? " Asking the following:
Do we know what cells we want to get rid of or how powerful the anti-iL-6R drug KEVZARA is in that fight? ... My own digging suggests that research is ongoing certainly for the first question ( meaning - there is probably antigen presentation to CD4+ T cells) . I ask those in group who are starting on KEVZARA - how has the pathophysiology of PMR been presented to you **? Have you been coached to imagine the drug working ?   As an example , using "guided imagery" is where a person with cancer imagines Pac Men (from the old Pac Man video game) gobbling up bad cancer cells.
* *Well today i stumbled upon a very informative video given by Leonard Calebrese ,DO from the Cleveland Clinic. It explains many things about the IL-6 pathway in a concise way !! If john would approve the link it is pmrandil6-dot-com and under the resources tab you eventually get to a video you can play . I will share this instead of a 10 page manuscript ( e.g. the 2022 review Ingrid E. Lundberg et,al.) to my non- science friends and family : )