@becsbuddy hello, no the reumathologist doesnt understand why in first place the biologic works for tha mind (brain fog, anxiety and fatigue). In my case works better than anything not onlyfor my still disease body symptoms but for mental clarity too!!! Many patients experience this good effect but there are no studies about the correlation. So, when it starts to loose effect, close to the next shot, is when my mind suffers. Most of the month I am clear headed and on good mood and no fatigue. I think cytokines mess with the nervous system but there are few studies about that. I can discuss that with the psychiatrist next appointment in august. Ive noticed that since using the biologic, medications for the mind (including cbd and some “natural” too) had the opposite effect. Ive usted this cbd before with complete success on anxiety and sleep. Now I cant metabolize it the same it makes my mind slow the sabe with ssri