I have been on the medication for 7 weeks. My oncologist just told me to stop taking the medication for 2 weeks and let me body adjust. We will then see the next step and what other Ai might work better or perhaps a smaller dose. What works for my knee pain is exercise and yoga. I do it everyday. When I sit too much is when my knee pain kicks in. Being off the pill for 2 weeks will show me whether the AI is exacerbating my arthritic knees.