Background-I was diagnosed with Stage IIIB ER+, PR+, HER2+ ductal and lobular cancer last June. I was put on a clinical trial which includes taking anestrozole for 6 months and then surgery. Although my K2 numbers last September showed the anestrozole was ‘activating’ the cancer cells, the tumor neither diminished nor grew. It’s still at 9cm. The first two months of taking it were rough, but after that I adjusted to it and now I sometimes wonder if I’m taking a placebo. The only side effects are some irrational emotions and fatigue, both which could be attributed to just having cancer. Im having a double mastectomy with two different surgeries, the first one on the 23 of this month. After that I’ll go back on the anestrozole