@johnbishop, @danye1, and all...Hello John and Danye1, yes, I have the cramping issue frequently at night while going to sleep, at times waking me in sharp agony while sleeping, and at times while awake.
I have neuropathy, one part of the problem. I was diagnosed with Restless Leg Syndrom by the Mayo sleep study as well. They tested my blood ferritin level, iron protein that carries oxygen to the blood to various organs to keep us going, because they diagnosedsevere RLS, and have found ferritin levels are often low with RLS. Never tested ferritin levels before.

So, my ferritin was very low, I was given 2 iron infusions, IV iron a week apart. It made an enormous difference. The RLS settled down quickly. Cramping was far less. I began to feel better during the day, more energy than in years and could lift my legs and feet and walk better. Wow!
I also began taking magnesium supplements daily. That helps. Naturally, be sure to drink enough water daily.

I never had botox injections for this issue. I think my needs are increased and regular ferritin...IV infusions every few months. Magnesium supplements daily. And, I have a prescription cream, magnesium sulfate, that helps and I use it when needed.
All in all, I'm a much happier woman with better sleep and fewer nights in agony. I am so thankful for the ferritin cks and treatments. Changed my life.

I will add, I saw a Mayo hematologist yesterday for the low ferritin and wonky iron profile numbers that keep popping up. My PCP was concerned as was having low oxygen saturation and out of bounds othe profile numbers...and no one was addressing these issues...it seems I have absorption problems, with B12, D3, ferritin, magnesium, and other deficiencies. Have celiac disease. Just identified last week. Intestines don't absorb nutrients properly. I've been adding oral supplements for years in all these areas. Hematology suggested I stop the B12 shots, the B supplement, the anemia supplement, iron supplement, and have blood work to check levels in 6 weeks. They'll be low, so I'll begin regular IV supplementation on regular basis. This avoids the digestive tract, delivers the substance efficiently, my organs get oxygen and minerals they need, I save hundreds of $in supplements that don't work as well...quite a big deal in my life. A good doctor who analyzes clearly and follows through to an improved treatment.
Just added that info to let you know there are doctors out there who do think out of the box and investigate for your best interests. Amazing. After 50 years, I'm 76, I'm seeing one of them. Grateful isn't a strong enough word. This is miraculous.
Hope some of this helps. Blessings, Elizabeth.