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Concerned about the side effects of anastrozole

Breast Cancer | Last Active: Apr 27 1:15pm | Replies (1931)

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@elizm

to @islandelder and @samanthavon and @roch : I'm guessing that the radiation was not a direct cause of the emotional upsets... rather the AI is the culprit. AIs mess with our hormones (and cause a dozen or so other side effects at times). I haven't acquired trigger finger (yet), but I do get infrequent bouts with carpal tunnel syndrome from the Anastrozole. Luckily, I know how to treat it by soaking it in warm water and wearing a wrist brace at night.

As noted a few months ago in this forum, because I am so hypersensitive to most pharmaceuticals, I made the decision to take only half an Anastrozole/day... much to the disgruntlement of my oncologist. I explained that most women give up on AIs after about 2 years because of the side effects. I can manage a half dose for the seven years he has prescribed. In addition, getting one's Vitamin D3 to a high level also reduces circulating estrogen and other sex hormones, according to a Fred Hutchison Cancer Research Center study in 2016. I don't mind taking 2000 IUs of micellized D3 with the half dose of Anastrozole to achieve the goal.

For those whose hair may be thinning... my oncologist prescribed 50 mg/day of Biotin (50,000 mcg) for me when I was post-chemo. My hair has come back thicker than before chemo. I recently reduced the dose to 10 mg, which is still a lot. [A word of warning: if your doctor ever decides to test your thyroid, stop taking the Biotin a few days before the test or the result will imply that you are hyperthyroid which causes all sorts of pandemonium. It's just the Biotin messing with test.]

For the emotions component of estrogen reduction, the remedy which seems to suit me best is good ol' exercise... at least 4 times a week I do a fast mile walking on the treadmill which is about all I can handle with the chemo-induced peripheral neuropathy... but it does the trick for mesamanthavon I'm guessing that the radiation was not a direct cause of the emotional upsets... rather the AI is the culprit. AIs mess with our hormones (and cause a dozen or so other side effects at times). I haven't acquired trigger finger (yet), but I do get infrequent bouts with carpal tunnel syndrome from the Anastrozole. Luckily, I know how to treat it by soaking it in warm water and wearing a wrist brace at night.@

As noted a few months ago, because I am so hypersensitive to most pharmaceuticals, I made the decision to take only half an Anastrozole/day... much to the disgruntlement of my oncologist. I explained that most women give up on AIs after about 2 years because of the side effects. I can manage a half dose for the seven years he has prescribed. In addition, getting one's Vitamin D3 to a high level also reduces circulating estrogen and other sex hormones, according to a Fred Hutchison Cancer Research Center study in 2016. I don't mind taking 2000 IUs of micellized D3 with the half dose of Anastrozole to achieve the goal.

For those whose hair may be thinning... my oncologist prescribed 50 mg/day of Biotin (50,000 mcg) for me when I was post-chemo. My hair has come back thicker than before chemo. I recently reduced the dose to 10 mg, which is still a lot. [A word of warning: if your doctor ever decides to test your thyroid, stop taking the Biotin a few days before the test or the result will imply that you are hyperthyroid which causes all sorts of pandemonium. It's just the Biotin messing with test.]

For the emotions component of estrogen reduction, the remedy which seems to suit me best is good ol' exercise... at least 4 times a week I do a fast mile walking on the treadmill which is about all I can handle with the chemo-induced peripheral neuropathy... but it does the trick for me.

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Replies to "to @islandelder and @samanthavon and @roch : I'm guessing that the radiation was not a direct..."

@elizm I've started taking the anastrazole at night instead of in the morning, hoping any emotional wiggles will be gone by morning. Not looking forward to more joint pain. I'm 81 years old--my joints are already complaining! Thank you for your detailed answer. I've always been physically active but I've slacked off since this happened. I'm going to get back at it. I'm sure it will help.