to ajh5285 below are some links to articles I've read about curcumin. I too have difficulty getting answers from oncologists about off label drugs and supplements. My husband has Stage IV and is getting chemo, and we have discussed baby aspirin, metformin and tumeric(circumin) w the drs. He takes Vit D and Zinc and they don't have a problem w that. He is treated at Dana, but we also went to Sloan this week. They have more of an integrative medicine dept there, and we are going to do a telemed call with that dept. See the link below. Sloan has a detailed website that describes all the supplements. The dr at Sloan didn't have an issue with him taking Vit D either. The site does not list the contraindications for curcumin to include the chemo--they list only possibility of kidney stones. All the drs want "evidence based clinical trials" for these off label drugs, even if there are numerous articles or smaller trials that have been done. BUt did you know that if a drug company sponsors a trial that they very often withhold the clinical trial results from the drs? The drug companies control the information and the marketing, so I'm not sure how good that "evidence" is, if the trials are not peer reviewed. And big pharma will not pay for clinical trials for an off label drug where the patent is gone, because they can't make money. There is a clinical trial at MD ANderson for hydroxycholoroquine, and I have inquired about that. It's very difficult to get consistent answers on the vitamins/supplements/off label drugs. Here are links:
Curcumin Combination Chemotherapy: The Implication and Efficacy in Cancer - PubMed (nih.gov)
Turmeric | Memorial Sloan Kettering Cancer Center (mskcc.org)
Curcumin-cisplatin chemotherapy: A novel strategy in promoting chemotherapy efficacy and reducing side effects - PubMed (nih.gov)
Curcumin and its derivatives in cancer therapy: Potentiating antitumor activity of cisplatin and reducing side effects - PubMed (nih.gov)