This lead-in from the WSJ, 5-23-23 if you subscribe to it, very interesting article in the study of chronic pain:

Electrodes embedded in the brains of four people have captured a detailed and precise portrait of chronic pain.

The new work, published Monday in the journal Nature Neuroscience, points to brain regions that could be targets for future treatments, neuroscientists say, while adding to our understanding of why some people develop persistent, unyielding chronic pain.