I started Anastrozole immediately after my mastectomy in 2016, my oncol. did not discussed sideeffects. I did however notice he was overly concerned about my ankles and pain in ankles-I had no complaints. Now in 2018, I have sleepless nights, horrible depression,horrible joint and bone pain and my hair is thinning. I have grown my hair past my butt and it has been increasingly thin on top and throughout. I have a different Oncol. and it seems it takes an act of God to get her to switch me to a different pill. I have to take this pill x 10 years, don't think I will make it that long.