I just discovered this discussion group today. I was diagnosed with stage 1A breast cancer in July 2016. I have been off and on Anastrozole since January 2017. I have had serious hand pain in my right hand only. My ring finger is the worst, stiff and clicking. usually improves as the days goes on. About a week ago my right thumb suddenly started to ache and click when I flex it to the point where I have to take ibuprofen to be comfortable doing routine tasks like peeling potatoes. I have also had a lot of trouble with my eyes sticking shut while I'm sleeping and having to literally pry them open during the night when it wakes me up. Dry eyes the eye doctor told me and said I should use eye drops, etc. This is helping a little. I was switched to Exemestane for about two months and nothing improved. I went off everything for about 6 weeks this summer and the hand pain decreased but the eye problem did not. I have now been back on Anastrozole for about two months, and now the hand is getting even worse than it was before. Legs starting to hurt while sleeping. No hair thinning that I have noticed. Eyes the same. I have an appt. with oncologist i November and will evaluate going off the drug. Will this get better if I stay on for six months? I am afraid the hand pain is becoming permanent.