Hi @nicolaidk, I see that you found another active EGFR discussion. That includes some valuable information. I'm hoping one of the other EGFR survivors may respond here too.
I'm an ALK patient, a different mutation, stage IV. I am still taking my first TKI and doing fairly well, but I'm always looking to 'what's next'. Hopefully your wife has a long run on the Tagrisso. It really helps me to deal with the uncertainty to know what happens when I inevitably experience progression. I'm an analytical person, and having a plan is important to me. Cancer patients and caregivers generally don't like surprises! I was diagnosed three years ago, and even over that time, the plan of 'what's next' has changed, mostly due to ever advancing research and new clinical trials. Many thanks to great scientists that are much much smarter than me!
There is an EGFR Facebook group that may be helpful, "EGFR Resisters Lung Cancer Patient Group". There is a comparable ALK group that has been valuable to me in learning about ALK, future treatments, and on-going clinical trials.