I've got lots of good things to say about it. I went on it in May of 2019 and in two days it stopped my "non moving" pain. And it healed my small intestine in about 2 months. It had been plagued by small ulcers for a couple of years. As far as PMR symptoms go, I can't tell if it has been a real help. I have changed rheumatologist and negotiating with the new one about the LDN. She knows about it but has never used it. She promises to take a hard look at it. I have gone off of it for now and will report to her on how it goes. Ideally, my GI doc should be the one 'scribing it but that medical community is behind accepting it. Over 80 % of the Crohn's patients get some benefit from it. As I can testify.