Unfortunately, that is an unknown. I wish there were studies on long term use of HRT particularly since the hormones we use today are vastly different in their source and delivery system than the ones used in the WHI. Once that study was shut down, along with the general use of HRT, that was it, it was considered a closed case, done deal. The big takeaway from the WHI was that it increased breast cancer risk by 25% which sounds horribly scary. The reality is that the placebo group in the study had 4 cases of breast cancer per 1,000 participants and the HRT group had 5 cases per 1,000. One additional case per 1,000 is calculated at a 25% increased risk. The media ran with the 25% increased risk.
I just listened to a very interesting podcast with Peter Attia interviewing one of the authors of the study.
https://peterattiamd.com/joannmanson/

Hello! I’m coming up on 80 and have been taking Estradiol .025 for two years.

I originally requested it for hot flashes even though I had a hysterectomy 30 years ago. (I took Premarin for 25 years after the surgery until my doctor took it away).
I feel wonderful - no more hot flashes, UTIs or dryness.

I’m hoping my ostiopenia has improved also because Reclast makes me feel horrible and I hate it.

I’m not a doctor but from my experience age obviously is not a factor.